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Li Shen, PhD



950 W. Walnut St.
R2 E124
Indianapolis, IN 46202

(317) 278-0498 (Office)
(317) 278-2011 (Lab) 

shenli@iupui.edu 

NIH Biosketch
(*.pdf)

 Li Shen, Ph.D. 
Assistant Professor, Department of Radiology

Education/Training:
Ph.D. Dartmouth College (2004)
M.S.  Shanghai Jiao Tong University (1996)
B.S.  Xi'an Jiao Tong University (1993)


Imaging Genomics Lab

Welcome to the Laboratory of Li Shen at the Indiana University School of Medicine. Our laboratory is focused on research and training in medical image computing, computational biology, and bioinformatics. We study cutting-edge computational and informatics methods, and turn them into practical tools that can help computers better understand digital data (e.g., 1-D sequences, 2-D images, and 3-D shapes) in practical applications. In particular, we are currently working on various neuroimaging and genomics projects. In these projects, we apply, extend or develop state-of-art software tools for analyzing structural and functional neuroimaging data as well as genomic and other related biomarker data. The ultimate goal is to improve early diagnosis and mechanistic understanding of disease processes and treatment response for brain disorders such as Alzheimer's disease and schizophrenia, as well as the cognitive effects of cancer chemotherapy. The computational methods we study include (1) image & vision computing, (2) data mining & pattern recognition, and (3) geometric modeling & graphics.

http://www.iupui.edu/~shenlab/publications.html


Selected Publications: 


Shen L, Farid H, and McPeek MA. Modeling 3-dimensional morphological structures using spherical harmonics. Evolution. In press.

McPeek MA, Shen L, and Farid H. The correlated evolution of 3-dimensional reproductive structures between male and female damselflies. Evolution. In press.

Shen L, Firpi HA, Saykin AJ, West JW. Parametric surface modeling and registration for comparison of manual and automated segmentation of the hippocampus. MICCAI 2008 Workshop on the Computational Anatomy and Physiology of the Hippocampus, NYC, Sep 6, 2008.

McPeek MA, Shen L, Torrey JZ, and Farid H. The tempo and mode of 3-dimensional morphological evolution in male reproductive structures. American Naturalist, 171(5):E158-E178, 2008.

Huang H, Shen L, Ford JC, Wang Y, and Xu Y. Computational issues in biomedical nanometrics and nano materials. Journal of Nano Research, Inaugural Issue, Vol. 1:50-58, 2008.

Shen L, Saykin AJ, Firpi HA, West JD, McHugh TL, Wishart HA, Flashman LA, Wessels AM, McDonald BC, Cannon A. Comparison of manual and automated determination of hippocampal volumes in MCI and older adults with cognitive complaints. Alzheimer's & Dementia, Vol. 4, Iss. 4, Suppl 2:T29-30, 2008.

Huang H, and Shen L. Three dimensional model for cardiac bioelectricity simulation: cell to organ. Simulation: Transactions of the Society for Modeling and Simulation International, 83(4): 321-327, 2007.

Huang H, Shen L, Zhang R, Makedon FS, Saykin AJ, and Pearlman JD. A novel surface registration algorithm in medical modeling applications. IEEE Transactions on Information Technology in Biomedicine, 11(4): 474-482, 2007.

Chung MK, Dalton KM, Shen L, Robbins SM, Evans AC, and Davidson RJ. Weighted fourier series representation and its application to quantifying amount of gray matter. IEEE Transactions on Medical Imaging, Special Issue on Computational Neuroanatomy (invited paper), 26(4): 566-581, 2007.

Shen L, Saykin AJ, Chung MK, and Huang H. Morphometric analysis of hippocampal shape in mild cognitive impairment: an imaging genetics study. IEEE 7th International Symposium on Bioinformatics and BioEngineering, pages 211-217, Boston, MA, October 14-17, 2007.

Shen L, Huang H, Makedon FS, and Saykin AJ. Efficient registration of 3D SPHARM surfaces. CRV 2007: Fourth Canadian Conference on Computer and Robot Vision, Montreal, QC, pages 81-88, May 28-30, 2007.

Huang H, Shen L, Zhang R, Makedon FS, Hettleman B, and Pearlman JD. Cardiac motion analysis to improve pacing site selection in CRT. Journal of Academic Radiology, Elsevier Science, 13(9):1124-1134, September 2006.

Shen L, and Makedon FS. Spherical mapping for processing of 3-D closed surfaces. Image and Vision Computing, 24(7): 743-761, 2006.

Shen L, Zheng W, Gao L, Huang H, Makedon FS, and Pearlman JD. Spatio-temporal modeling of lung images for cancer detection.   Oncology Reports, Special Issue on Computational Analysis and Decision Support Systems in Oncology, 15:1085-1090, 2006.

Shen L and Chung MK. Large-scale modeling of parametric surfaces using spherical harmonics. IEEE 3DPVT 2006: Third International Symposium on 3D Data Processing, Visualization and Transmission, UNC, Chapel Hill, USA, June 14-16, 2006.

Shen L, Ford JC, Makedon FS, and Saykin AJ. A surface-based approach for classification of 3D neuroanatomic structures. Intelligent Data Analysis, An International Journal, 8(6):519-542, 2004.