Jinhui Chen, M.D., Ph.D.
Associate Professor of Neurological Surgery
Ph.D., Institute of Biochemistry and Cell Biology, Chinese Academy of sciences (1997)
Research Associate, Washington University School of Medicine in St. Louis (1998-2000)
Postdoctoral Fellow, Harvard Medical School (2000-2003)
Neural degeneration and regeneration in the hippocampus following traumatic brain injury.
Stem cell research offers unprecedented opportunities to explore fundamental questions of biology and to develop novel medical therapies for debilitating diseases such as injury, neurodegenerative diseases and aging. The long-term goals of my laboratory are to explore the molecular and cellular mechanisms that regulate neurogenesis in the adult hippocampus and to seek the potential of stem cells for repairing neocortical circuitry damaged by traumatic brain injury. We are interested in understanding cellular and molecular mechanisms that are responsible for neural stem/progenitor cell fate determination and development of adult-born neurons in the normal or injured brain. The methods we use to pursue this goal include conditional knockout, primary culture, videomicroscopy (real-time imaging), confocal imaging, virology, histology, biochemistry, and molecular biology.
Selected Peer-reviewed Publications:
Huashun Li*, Jinhui Chen*, Wei wu*, Tanya Fagaly, Lijuan Zhou, Wenlin Yuan, Sophie Dupuis, Zhihong Jiang, William Nash, Carrie Gick, David M. Ornitz, Jane Y. Wu, Yi Rao. (1999) Vertebrate Slit,a Secreted Ligand for the Transmembrance Protein Roundabout, is a Repellent for Olfactory Bulb Axons. Cell, 96: 807-818 *(equal contribution).
Wei Wu, Kit Wong, Jinhui Chen, Zhihong Jiang, Jane Y. Wu, Yi Rao. (1999) Directional Guidance of Neuronal Migration in theOlfactory System by the Secreted Protein Slit. Nature (article), 400: 331-336.
Wenlin Yuan, Lijuan Zhou, Jinhui Chen, Jane Y. Wu, David M. Ornitz. (1999) The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Developmental Biology, 212:290-306.
Jinhui Chen, Wei Wu, Huashun Li, Tanya Fagaly, Lijuan Zhou, Jane Y. Wu, Yi Rao. (2000) Embryonic expression, extracellular secretion, and chemorepulsive activity of Xenopus Slit. Neuroscience, 96: 231-236.
Jinhui Chen, Leng Wen, Sophie Dupuis, Jane Y. Wu, Yi Rao. (2001) The N- terminal Leucine-Rich Regions in Slit Are Sufficient to Repel Olfactory Bulb Axons and Subventricular Zone Neurons. J of Neuroscience, 21(5): 1548-1556.
Nicolas O. Fortunel, Hasan Otu, Huck-Hui Ng, Jinhui Chen, Xiuqian Mu, Timothy Chevassut, Xiaoyu Li, Marie Joseph, Charles Bailey, Jacques A. Hatzfeld, Fatih Usta, Vinsensius B. Vega, Philip M. Long, Towia A. Liberman, Bing Lim. (2003) Comment on “Stemness: Transcriptional Profiling of Embryonic and Adult Stem Cells” and “A Stem Cell Molecular Signature” (I). Science. 302, 393.
Jinhui Chen, Sanjay S. Magavi, Jeffrey D. Macklis. (2004) Neurogenesis of corticospinal motor neurons extending Spinal Projections in adult mice. PNAS, 101, 10357-62.
Polar Attlota, Bradley J. Molyneaux, Jinhui Chen, Jun Inoue, Ryo Kominami, & Jeffrey D. Macklis. (2005) Neuronal Subtype Specific Genes that Control Corticospinal Motor Neuron Development in vivo. Neuron, 45, 207-21.
Xiang Gao, Polar Attlota, Jeffrey D. Macklis, Jinhui Chen. (2007) Conditional knok-out of b-catenin in postnatal-born dntate gyrus granular neurons results in dendritic malformation. Journal of Neuroscience. 27(52): 14325-14317.
Xiang Gao, Ying Deng, Wongil Cho, Edwards D. Hall, Jinhui Chen. (2008) Selective death of newborn neurons in hippocampal dentate gyrus following moderate experimental traumatic brain injury. Journal of Neuroscience Research. 86(10):2258-2270.
Xiang Gao, Jinhui Chen. (2008) Direct isolation of neural stem cells in the adult hippocampus after traumatic brain injury. Journal of Neurotruma. 25(8):985-995.
Xiang Gao, George Smith, Jinhui Chen (2009) Impaired dendritic development and synaptic formation of postnatal-born dentate gyrus granular neurons in the absence of brain-derived neurotrophic factor signaling. Experimental Neurology. 215, 178-190.
Xiang Gao, Jinhui Chen (2009) Conditional knockout of brain-derived neurotrophic factor in the hippocampus increases death of adult-born immature neurons following traumatic brain injury. Journal of Neurotrauma. 26, 1325-1335.
Xiang Gao, Jinhui Chen (2009) Moderate traumatic brain injury promotes proliferation of quiescent neural progenitors in the adult hippocampus. Experimental Neurology. 219, 516-523.
Xiang Gao, Jinhui Chen (2011) Mild traumatic brain injury results in extensive neuronal degeneration in the cerebral cortex. J of Pathology and Experimental Neurology. 70(3): 183-191.
Joel M. Brittain, Liang Chen, Tatiana Brustovetsky, Xiang Gao, Nicole M. Ashpole, Sarah M. Wilson, Andy Hudmon, Fletcher A. White, Nikolay Brustovetsky, Jinhui Chen, and Rajesh Khanna. (2011) Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP-2). J Biological Chemistry. 286(43):37778-92.
Xiang Gao, Ping Deng, Zhao C. Xu, Jinhui Chen (2011) Traumatic brain injury causes acute dendritic and synaptic degeneration in hippocampal dentate gyrus PlosOne. 6 (9), e245666-e24566.
Chandler L. Walke, Melissa J. Walker, Nai-kui Liu, Emelie C. Risberg, Xiang Gao, Jinhui Chen, and Xiao-Ming Xu. (2011) Bisperoxovanadium promotes neuroprotection and functional recovery after cervical contusive spinal cord injury: a possible mechanism involving Akt/mTOR activation. PlosOne 2012;7(1):e30012. Epub 2012 Jan 10.
Hongzhen Zou, Liang Chen, Bingde Luo, Jinhui Chen (2012) Moderate traumatic brain injury triggers rapid necrotic death of immature neurons in the hippocampus. J of Pathology and Experimental Neurology. 71(4): 348-59.
Xiang Gao, Jinhui Chen. (2013) Moderate Traumatic Brain Injury Promotes Neural Precursor Proliferation Without Increasing Neurogenesis In The Adult Hippocampus. Experimental neurology. 239: 38-48.